时间：2021年9月17日（周五）上午10:00-11:00

Time: 10:00-11:00AM，Friday, September 17,2021

地点：西湖大学云栖校区2号楼213室

Venue: Room 213, Building 2, Yunqi  Campus

主持人：西湖大学工学院张科春博士

Host:  Dr. Kechun Zhang, PI of School of Engineering

主讲嘉宾/Speaker：

Prof. Xiangcheng Zhu

Xiangya international academy of translational medicine, Central South University

Director of Microbiology Laboratory in National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery

讲座摘要/Abstract:

Cancer is the major threat to public health. The antibody-drug conjugate(ADC) has become one of the hot spots because of its targeted strong tumor killing effect. Enediynes are one family of the most toxic microbial natural products demonstrating great potential as warheads for the development of ADC anticancer drugs. Among them, 10-membered anthraquinone fused (10-AqF) enediynes, exemplified by Tiancimycins (TNMs), are particularly interesting due to the compact and relatively stable structures. However, the acquisition of such drug leads is challenging with extremely low synthetic or microbial fermentation yields, which hampered their subsequent clinical studies. Recent biosynthetic studies have revealed that 10-AqF enediynes follow a common pathway to achieve their microbial production. Herein, The Zhu lab started from the original TNM-producing strain Streptomyces sp. CB03234, and stepwisely improved the titer of TNMs through strain breeding, medium optimization and multi-omics directed metabolic engineering. Based on these efforts, a practical platform for efficient microbial production of 10-AqF enediynes is constructed that will facilitate their studies in clinical trials.

讲座联系人/Contact:

工学院聂梦真

niemengzhen@westlake.edu.cn