时间：2025年9月18日（周四）下午14:00-15:00

Time：14:00-15:00, Thursday, September 18, 2025

主持人: 西湖大学交叉科学中心助理教授，杨一帆博士

Host: Prof. Yifan Yang, Assistant Professor, Center for Interdisciplinary Studies (CIS), Westlake University

地址：西湖大学云谷校区E10-201

Venue: E10-201, Yungu Campus, Westlake University

讲座语言：英文

Lecture Language: English

Prof. Uri Alon

Member, The Israel Academy of Sciences and Humanities

Abisch-Frenkel Chair Professor, Weizmann Institute of Science

主讲人/Speaker：

Uri Alon is a pioneer of systems biology, the field that seeks to uncover the principles by which biological components work together to produce adaptive and robust systems. Trained as a physicist and later transitioning to biology during his postdoctoral work with Stanislas Leibler, he has made foundational contributions to the development of systems biology, including the discovery of network motifs and insights into p53 oscillations. He is the author of influential books, including “An Introduction to Systems Biology: Design Principles of Biological Circuits” and “Systems Medicine”, which have trained generations of researchers worldwide. Beyond research, he is widely known for his lectures on creativity and the human side of science, as well as for his memorable performances combining science and guitar playing. In recent years, his research has expanded toward the systems biology of human physiology, tissue biology, diseases & aging.

讲座摘要/Abstract:

Fibrosis—excessive scarring that disrupts tissue function—remains one of the largest unmet challenges across medicine, contributing to chronic organ failure in the lung, liver, kidney, and heart. The underlying processes of inflammation, repair, and scarring involve hundreds of cell types, signals, and feedback loops, making the system dauntingly complex. In this lecture, I will present a simplifying conceptual framework that distills this complexity into universal modules of inflammation and repair. Using experimental results together with mathematical models, I will show how positive feedbacks between damage signals, immune cells, and fibroblasts can drive tissues toward either resolution and healing, or runaway scarring. This approach has not only clarified fundamental principles of inflammatory repair, but also inspired preclinical strategies. In mouse models, targeting key feedback motifs has led to molecules that prevent—and in some cases even reverse—fibrosis. By combining theory with experiment, we aim to bring a measure of simplicity to a notoriously complex problem, opening new avenues for therapeutic intervention.

讲座联系人/Contact:

交叉科学中心，杨一帆实验室，刘兰凝，邮箱：liulanning@westlake.edu.cn

Center for Interdisciplinary Studies (CIS), Ms. Lanning Liu, Email: liulanning@westlake.edu.cn