时间: 2025年9月3日（周三）16:00-17:30

Time: 16:00-17:30, Wednesday, September 3, 2025

主持人: 西湖大学理学院PI张鑫教授

Host: Prof. Xin Zhang, PI of School of Science, Westlake University

地址：西湖大学云谷校区E10-201

Venue: E10-201, Yungu Campus, Westlake University

讲座语言：英文

Lecture Language: English

郭子建院士

中国科学院院士、发展中国家科学院院士，南京大学

Prof. Zijian Guo

Member of the Chinese Academy of Sciences (CAS), Fellow of the Third World Academy of Sciences (TWAS), Nanjing University

主讲人/Speaker:

Dr. Zijian Guo received his PhD degree from the University of Padua and worked as a post-doc fellow and a research associate at the University of London and the University of Edinburgh successively. He joined Nanjing University in 1999 and served as the director of the State Key Laboratory of Coordination Chemistry from 2000 to 2009 and the dean of the School of Chemistry and Chemical Engineering from 2006 to 2014. He is currently a professor of the School of Chemistry and Chemical Engineering and the director of the Chemistry and Biomedicine Innovation Center of Nanjing University. His research focuses on the chemical biology of metals and metallodrugs including the metal-based anticancer complexes and their targeted delivery, the fluorescent sensors for bio-metals, and the role of metals in immunology. He serves as editorial/advisory board members of several international journals, and was appointed as the editor-in-chief of Chemical & Biomedical Imaging, a new journal jointed launched by the American Chemical Society and Nanjing University. He was the winner of the Luigi Sacconi Medal of Italian Chemical Society in 2016 and the Outstanding Achievement Award of Asian Society of Biological Inorganic Chemistry in 2020. He is a member of the Chinese Academy of Sciences (CAS) and a fellow of the Third World Academy of Sciences (TWAS).

讲座摘要/Abstract:

Platinum-based anticancer drugs play an important role in the treatment of various malignancies such as colorectal and testicular cancers. However, drug resistance and toxic side effects are challenging problems that hinder their wider clinical applications. Rational design of novel platinum complexes could provide useful tools for understanding the biomedical effects of platinum anticancer complexes in cellular energy conversion, metabolism and apoptosis, and enables the incorporation of multi-functionalities in the platinum core.

In this lecture, I will focus on the molecular design of platinum-based antitumor complexes with multi-modalities. These results demonstrated that in addition to DNA binding, bio-energetic pathways may also play crucial roles in the antitumor activity of mitochondrion-targeted platinum complexes. The combination of chemotherapy and immunotherapy in one molecule offers potential superiority for combating cancers. Radiation-induced activation of platinum(IV) prodrugs could become a powerful tool in combining the advantages of both chemotherapy and radiotherapy.

讲座联系人/Contact:

理学院，梁子微，邮箱：liangziwei@westlake.edu.cn

School of Science, Ziwei Liang, Email: liangziwei@westlake.edu.cn