时间：2022年7月1日（周五）16:00-17:30

Time: 16:00-17:30, Friday, Jul 1^st, 2022

线上：ZOOM ID 891 7137 3287

Online: ZOOM ID 891 7137 3287

主持人: 西湖大学理学院 张鑫 博士

Host: Xin Zhang, Professor, School of Science, Westlake University

主讲嘉宾/Speaker：

Prof. Yan Yu

Associate Professor

Department of Chemistry

Indiana University-Bloomington

主讲人简介/Biography:

Prof. Yan Yu is an Associate Professor in the Department of Chemistry at Indiana University Bloomington. She received her B.S. in Chemistry from Peking University (Beijing, China) in 2004, and Ph.D. in Materials Science and Engineering at the University of Illinois-Urbana Champaign in 2009 under the direction of Prof. Steve Granick. She completed her postdoctoral training with Prof. Jay T. Groves at the University of California at Berkeley from 2009 to 2012. She joined the Department of Chemistry at Indiana University as an Assistant Professor in 2012 and was promoted to Associate Professor with tenure in 2019. Prof. Yan Yu has received the NSF CAREER award in 2016, Cottrell Scholar Award from the Research Corporation for Science Advancement in 2016, Maximizing Investigators’ Research Award from the National Institutes of Health in 2017, Trustees Teaching Award from Indiana University in 2017, Sloan Research Fellowship in 2017, Invitational Fellowships for Research in Japan in 2020, and a Scialog Award from the Research Corporation for Science Advancement in 2021.

讲座摘要/Abstract:

Understanding and controlling immune responses holds great promise for the development of precision medicine. Functions of immune cells depend on the intricately organized chemical reactions and physical forces. Examples range from the engulfment of invading bacteria that relies on a fine balance of competing mechanical forces, to the activation of T-lymphocytes that requires collective interactions between thousands of receptors at the junction between cells. Owing to the complexity of these processes, understanding immune functions using traditional biological tools alone is challenging. In this talk, I will present my group’s recent research progress toward the development of nanotechnology-based biophysical tools for the quantitative imaging and manipulation of immune cells during host-pathogen interactions. Our research so far has capitalized on Janus particles, which, like the two-faced Roman god Janus, are made chemically, biologically, optically or magnetically asymmetric. Integrating Janus particle-based toolsets with super-resolution microscopy, we uncovered new mechanisms in immune regulation, from receptor crosstalk, phagocytosis, to intracellular degradation, which would otherwise be difficult to access with traditional means.

讲座联系人/Contact:

工学院石怀玮

shihuaiwei@westlake.edu.cn